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ABSORPTION AND METABOLISM OF ZINC

02

Application of Zinc in Livestock and Poultry

Zinc is a component of many enzymes and functional proteins in the body, and is involved inCell proliferation and differentiation, gene transcription, translationlife activities, andAnimal growth and development, immune response, energy metabolism, endocrine regulation and reproductionand so on are closely related.

The effect of zinc on livestock and poultry is mainly reflected in the regulationintestinal function. Zinc has the characteristics of antioxidant, so the addition of zinc in livestock and poultry diets can beRelieve the intestinal oxidative stress and enhance the intestinal mucosal barrier of weaned piglets, regulate the intestinal flora of livestock and poultry, maintain the homeostasis of intestinal microenvironment, and reduce the occurrence of diarrhea.

Zinc can also affect intestinal immune function by activating various intestinal immune cell differentiation and immune signaling pathways.AndZincLack often leads to growth retardation, diarrhea, skin keratinization and decreased immune function and other adverse consequences, seriously affecting animal health.

03

Factors affecting the absorption and utilization of zinc in the body

according to reports,High calcium diets (especially diets for monogastric animals, poultry and fish) often lead to zinc deficiency. Calcium not only affects the absorption of zinc, but also affects the distribution of zinc in the body.

This is the relationship between calcium and zinc.antagonism. Other elements such as phosphorus, copper and iron have antagonistic relationship with zinc, and the competition between zinc and these elements will reduce its bioavailability.

In addition, the digestive tract environment (stomach, pancreas, bile and pH), the type and quantity of chelating agents in the diet and other dietary components, the physiological stage of livestock (growth, pregnancy, lactation, etc.) have important effects on the absorption and utilization of zinc.

The different forms of zinc addition also have an important effect on the absorption of zinc.

Since the 1990 s, many experiments have proved that there is a small peptide transport system in animals.Most of the final products of proteins in the digestive tract are often small peptides rather than free amino acids, which can be absorbed directly into intestinal mucosal cells by passive objects..

Le Guowei and others in the study of small peptide chelation trace elements in the report mentioned that the protein in the process of degradation to amino acids to produce a large number of intermediate small peptides, small peptides can be intact through the intestinal mucosal cells and enter the systemic circulation.

This is the small peptide absorption theory.

The theory holds that small peptides can be directly absorbed into the blood circulation in the form of peptides, and compared with the absorption of amino acids, it has the advantages of fast absorption, not easy to saturate, low energy consumption, and there is no competition between the small peptide absorption system and the amino acid absorption system.

Therefore, the small peptide chelate zinc, which uses the small peptide as a ligand, is absorbed and utilized by the body mainly through the absorption channel of the small peptide, and has more advantages in absorption and utilization efficiency than amino acid chelate zinc, inorganic zinc, etc.